Work

Enhanced Bone Regeneration by Schwann Cells through Coupling of Osteogenesis and Angiogenesis via β-catenin signaling in a Preclinical Model of Distraction Osteogenesis

Year: 2024

Type: article

Abstract: Through activation of AKT/GSK-3β/β-catenin signaling, SCs enhanced the coupled angio- and osteogenesis effects of BMSCs. The preclinical evidence demonstrates that SCs derived CM with increased neurotrophins secretion can be a promising treatment approach to accelerate bone regeneration in the DO process.

Source: International Journal of Medical Sciences

DOI: 10.7150/ijms.100854

Authors: Xiaoyu Wang, Yifan Yu, Rui Zhang, Jia Xu, Qinglin Kang

Institutions: Shanghai Jiao Tong University, Shanghai Sixth People's Hospital

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337