Year: 2024
Type: article
Abstract: This work reported the biotransformation of dehydroepiandrosterone 1 with Penicillium olsonii MRC500780. Structure determinations revealed that biotransformation of 1 by Penicillium olsonii MRC500780 afforded androst-4-ene-3,17-dione 2, 15α-hydroxyandrost-4-ene-3,17-dione 3, 3β,7β-dihydroxyandrost-5-ene-17-one 4, 3β,7α-dihydroxyandrost-5-ene-17-one 5, and 15α,17β-dihydroxyandrost-4-ene-3-one 6. This fungus primarily isomerized the starting material in terms of the double bond and the hydroxyl group at 3β oxidised, then hydroxylated it at the C-15α position and reduced it at the C-17 position; also, hydroxylations at the C-7α position and C-7β position were observed.
Authors: Ali Kuru, Mena Albayaty
Institution: Sakarya University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Funder: Sakarya Üniversitesi
OpenAlex ID: W4405257102