Work

Management of Intraoperative Sickle Crisis During Kidney Transplant in a Patient With Sickle Cell Disease: A Case Report

Year: 2024

Type: article

Abstract: A 31-year-old male patient with a history of sickle cell disease (SCD) with stage V chronic kidney disease (CKD) presented for a deceased donor kidney transplant. During surgery, the transplanted kidney showed mottling and limited cortical flow, raising concerns for an intraoperative sickle cell crisis versus hyperacute rejection. Postoperative imaging revealed decreased vascularity, and the patient was treated with RBC exchange. Pathology confirmed thrombotic microangiopathy without acute rejection. The patient's condition improved with supportive care, and he was discharged by postoperative day 10. This case highlights the complexity of managing SCD patients undergoing organ transplantation, with a focus on intraoperative challenges and postoperative care.

Source: Cureus

DOI: 10.7759/cureus.75562

Authors: Sanjeev Saravanakumar, Madeline R Skousen, Lynn D Cornell, Divya Shankaranarayanan, Pablo Serrano Rodriguez

Institutions: Mayo Clinic, George Washington University

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405265783