CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes
Year: 2024
Type: article
Source: Chemical Research in Toxicology
Authors: Laurent Leclercq, Ronald de Vries, Valérie Koppen, Peter Verboven, Filip Cuyckens, Inneke Wynant, Wim A. A. Vermeulen, Dean Naisbitt, Megan Ford, Xiaoli Meng, Shingo Sakamoto, Tamio Fukushima, Jan Snoeys
Institutions: Janssen (Belgium), University of Liverpool
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: closed
OpenAlex ID: W4405267255