Year: 2024
Type: article
Abstract: Myocardial ischemia-reperfusion injury (MIRI) is a serious injury to ischemic myocardium after blood flow recovery, and it is the focus and difficulty of cardiovascular disease treatment.The JAK/STAT signaling pathway is a double-edged sword in MIRI.The activation of STAT1 can promote cardiomyocyte apoptosis and aggravate myocardial injury.STAT3 can reduce myocardial injury by up regulating anti apoptotic protein, but inhibiting the activation of the JAK2/STAT3 signaling pathway under oxidative stress can protect myocardium.
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405267398