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Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023–2024

Year: 2024

Type: article

Abstract: We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro.

Source: Emerging infectious diseases

DOI: 10.3201/eid3101.241236

Authors: Jakob Ankerhold, Susanne Kessler, Martin Beer, Martin Schwemmle, Kevin Ciminski

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: European Commission, Deutsche Forschungsgemeinschaft, HORIZON EUROPE Framework Programme

OpenAlex ID: W4405279345

FWCI: 1.326

Cites: 10

Cited by: 5

Related to: 10