Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution
Year: 2024
Type: article
Abstract: The ventral pallidum (VP) is critical for motivated behaviors. While contemporary work has begun to elucidate the functional diversity of VP neurons, the molecular heterogeneity underlying this functional diversity remains incompletely understood. We used single-nucleus RNA sequencing and in situ hybridization to define the transcriptional taxonomy of VP cell types in mice, macaques, and baboons. We found transcriptional conservation between all three species, within the broader neurochemical cell types. Unique dopaminoceptive and cholinergic subclusters were identified and conserved across both primate species but had no homolog in mice. This harmonized consensus VP cellular atlas will pave the way for understanding the structure and function of the VP and identified key neuropeptides, neurotransmitters, and neurotransmitter receptors that could be targeted within specific VP cell types for functional investigations.
Source: Science Advances
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: Systems and Molecular Neurobiology Training Program, G1279095123, G2337220457, G2385889148, G2660677301, G3634464103, Dissecting the role of ventral pallidal projections to nucleus accumbens in reward processing, G9000003089, G9000118633, Spinal Mechanisms Underlying Interstitial Cystitis/Bladder Pain Syndromes (IC/BPS), Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intake, Dissecting ventral pallidal plasticity in punishment-resistant opioid self-administration, Cancer Center Support Grant, The WUSTL PREP post-bacc program to enhance doctoral readiness in neuroscience
OpenAlex ID: W4405280496