Work

Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure

Year: 2024

Type: article

Abstract: Pregnancy profoundly influences the pharmacokinetics of maternally administered drugs, necessitating a comprehensive understanding of placental transfer and fetal exposure for safe and effective drug therapy. This review provides an updated overview of recent advancements in the field, comprising placental anatomy and physiology, pharmacokinetic changes during pregnancy, factors affecting placental transfer, techniques for studying transfer mechanisms, and clinical implications for maternal and fetal health. Recent discoveries explaining placental structure, function, and molecular transport mechanisms underscore the complexity of drug transfer across the placental barrier. Advances in pharmacokinetic research reveal dynamic alterations in drug absorption, distribution, metabolism, and excretion during pregnancy, which impact therapeutic drug levels and maternal-fetal outcomes. Factors influencing placental transfer, including drug properties, placental transporters, and maternal-fetal physiology, are increasingly recognized as critical determinants of fetal exposure. Innovative methodologies and technologies facilitate the study of placental drug transport, offering insights into drug-specific transfer kinetics and developmental risks.

Source: Journal of Pharmacy And Bioallied Sciences

DOI: 10.4103/jpbs.jpbs_1215_24

Authors: Abdullah Duhaim, Tariq Abdullah Almatroudi, Zaiad Abdullah Alghidani, Abdulsalam Saad Alhunayni, Mohamed Helmy Salama

Institutions: Qassim University, Majmaah University

Language: English

Topic: Pregnancy and Medication Impact

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250