Work

Lamina Propria and GALT: Their Relationship with Different Gastrointestinal Diseases, Including Cancer

Year: 2024

Type: article

Abstract: The structural integrity of the gastrointestinal tract is important because it dictates the functionality of this system. Regarding this, GALT (gut-associated lymphoid tissues) have a significant role in immunity. Most cancer research focuses on organized lymphoid structures and less on diffuse structures such as the lamina propria (LP). Therefore, this paper aims to investigate the link between LP and cancer in humans. The interstitial matrix and loose connective tissue layer located directly under the epithelium is known as the LP. In this area, there are a lot of IgA+ plasma cells (PCs), T and B lymphocytes, macrophages, dendritic cells (DCs), and stromal cells (SCs). Antigens from the lumen are picked up by LP DCs and presented directly to B cells, which may cause IgA class switching and differentiation in the presence of T cells. In humans, the GALT of the mucosa has been proposed as the source of a unique malignancy known as "GALT carcinoma," which is thought to represent the "third pathway of colorectal carcinogenesis." However, present colorectal cancer classifications do not define GALT carcinoma as a separate histologic category.

Source: Gastrointestinal Disorders

DOI: 10.3390/gidisord6040066

Authors: Adrian Onisim Surd, Camelia Răducu, Eugen Răducu, Andrada Ihuț, Camelia Munteanu

Institutions: Iuliu Hațieganu University of Medicine and Pharmacy, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,364