Work

GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis

Year: 2024

Type: article

Abstract: mice induces weight gain, reduces adipose tissue wasting, ameliorates the motor function and muscle atrophy and prolongs the survival time. We report that microglial cells could be involved in mediating these effects because their depletion with PLX5622 reduces brainstem GDF15 expression, weight loss and the expression of lipolytic genes in adipose tissue. Altogether these results reveal a key role of GDF15-GFRAL signaling in regulating weight loss and the alteration of and lipid metabolism in the early phases of ALS.

Source: Brain Behavior and Immunity

DOI: 10.1016/j.bbi.2024.12.010

Authors: Germana Cocozza, Ludovica Maria Busdraghi, Giuseppina Chece, Antonio Menini, Marco Ceccanti, Laura Libonati, Chiara Cambieri, Francesco Fiorentino, Dante Rotili, Ferdinando Scavizzi, Marcello Raspa, Eleonora Aronica, Maurizio Inghilleri, Stefano Garofalo, Cristina Limatola

Institutions: Sapienza University of Rome, Roma Tre University, Amsterdam Neuroscience, Amsterdam University Medical Centers, University of Amsterdam, Istituto Neurologico Mediterraneo

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,880

Funders: Ministero della Salute, Sapienza Università di Roma, Stichting ALS Nederland, European Research Council, Ministero dell'Istruzione e del Merito

Awards: G2381290473, G3063883603, G3841605239

OpenAlex ID: W4405284295

FWCI: 2.522

Cites: 61

Cited by: 11

Related to: 10