Work

Marine ecosystems may offer environmental drugs for interventions in immunoinflammatory rheumatic diseases

Year: 2024

Type: article

Abstract: Marine ecosystems boast a rich biodiversity and chemodiversity.In recent years, the bioprospecting and screening for bioactive compounds revealed the existence of a plethora of new potential therapeutics in the oceans.Among these are secondary metabolites with potential applications in human immunoinflammatory diseases to mitigate oxidative stress and pro-inflammatory responses.Molluscs, sponges, corals and other metazoans, but also photosynthetic microorganisms and seaweeds, produce bioactive compounds which interfere with the main pro-inflammatory pathways involved in the pathogenesis and progression of chronic inflammatory diseases and autoimmune disorders.Several marine compounds have already reached the pre-clinical and clinical stage of investigation, and some are expected to enter clinical practice soon.In this review we cover the recent advancements in marine drug discovery related to antiinflammatory and immunomodulatory compounds and discuss their potential therapeutic applications.

Source: Journal of Environmental Rheumatology

DOI: 10.55563/jer/t2rspv

Authors: Rosanna Campitiello, Spiros Nicolas Agathos, Jian Li, Edoardo Andrea Cutolo

Institutions: Ospedale Policlinico San Martino, University of Genoa, Harbin Engineering University, UCLouvain, KU Leuven, Panzhihua University, University of Verona

Language: English

Topic: Marine Sponges and Natural Products

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405285837

FWCI: 0.168

Cites:

Cited by: 1

Related to: 10