Work

Trichostatin A reverses rocuronium resistance in burn-injured rats

Year: 2024

Type: article

Abstract: AIMS: This study aimed to investigate whether the histone deacetylase HDAC4 inhibitor, trichostatin A (TSA), could reverse resistance to non-depolarizing muscle relaxants (NDMRs) caused by burn injuries. MATERIALS AND METHODS: A rat burn injury model was established, in which TSA was administered to inhibit HDAC4 expression. The potency of rocuronium was assessed through tension tests, and the levels of HDAC4 and myogenin proteins were determined using Western blot. Additionally, siRNA was utilized to explore the effects of HDAC4 knockdown on rocuronium potency and protein expression. RESULTS: and lowered HDAC4 and myogenin protein expression in the subsequent burn injuries. CONCLUSION: The HDAC4 inhibitor TSA has the ability to mitigate NDMR resistance in skeletal muscle via the HDAC4-myogenin pathway after burn injuries.

Source: Burns

DOI: 10.1016/j.burns.2024.107351

Authors: Xiao Zhao, Huijuan Wang, Dian Xu, Junzuo Fu, Hong Wang

Institutions: Shanghai Jiao Tong University, Shanghai First People's Hospital

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,190