Year: 2024
Type: article
Abstract: The article presents a review of new data on blast cells metabolism and its regulatory mechanisms in acute myeloid leukemia. Particular attention is given to the role of reactive oxygen species in the regulation of signaling pathways and metabolic processes, as well as their influence on the aggressiveness and resistance to chemotherapeutic agents in acute myeloid leukemia. Elevated levels of reactive oxygen species are associated with altered activity of enzymes and proteins involved in cell proliferation and survival. The article also discusses data on the iron role in the formation of malignancy in acute myeloid leukemia.
Source: Oncohematology
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405287547