Promoting Prevention and Targeting Remission of Asthma
Year: 2024
Type: article
Abstract: Asthma is a common, multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes and endotypes and the availability of targeted biologic treatment options, the disease remains uncontrolled in a substantial proportion of patients with risk of exacerbations, requiring systemic corticosteroids, and with progressive disease. Current international guidelines advocate for a personalized management approach to patients with uncontrolled severe asthma. The European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) asthma expert panel was convened to discuss strategies to optimize asthma care and to prevent systemic corticosteroid overuse and disease progression. In this meeting report, we summarize current concepts and recommendations and provide a rationale to implement personalized asthma management at earlier stages of the disease. The ultimate goal is to move away from the current one-size-fits-most concept, which focuses on a symptom-driven treatment strategy, and shift toward a phenotype- and endotype-targeted approach aimed at curbing the disease course by improving clinical outcomes and preserving health-related quality of life. Herein, we provide a consensus view on asthma care that advocates a holistic approach and highlight some unmet needs to be addressed in future clinical trials and population studies.
Source: CHEST Journal
Institutions: Martin University Hospital, Comenius University Bratislava, NIHR Southampton Biomedical Research Centre, University of Southampton, Hygeia Hospital, Baylor College of Medicine, Queen's University Belfast, University of Oxford, NIHR Oxford Biomedical Research Centre, Hospital Universitario La Paz, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Hospital La Paz Institute for Health Research, Centro de Investigación Biomédica en Red, University of Edinburgh, Amsterdam University Medical Centers, Universidad Autónoma de Madrid, Ghent University, KU Leuven, University College London, Lund University, Skåne University Hospital, University Medical Center Groningen, University of Groningen, Charles University, Thomayer University Hospital, UCLouvain
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
OpenAlex ID: W4405287962