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Clinical Outcomes of Gestational Trophoblastic Neoplasia Patients Treated in a Tertiary Care Centre

Year: 2024

Type: article

Abstract: Gestational Trophoblastic Neoplasia (GTN) is a rare but highly curable condition arising from abnormal placental tissue. This retrospective study, conducted at Calicut Medical College, Kerala, from 2016 to 2019, evaluated the clinical and demographic profile, treatment outcomes, and fertility impacts in 25 patients diagnosed with GTN. Most patients were aged 20 - 35 years, with multiparous women showing a higher risk. Complete hydatidiform mole was the most common histopathological finding (60%), and 84% of patients were diagnosed at an early stage. Low - risk GTN cases responded well to single - agent chemotherapy, primarily Methotrexate, with a 100% treatment success rate. High - risk cases required more intensive regimens and occasional surgical interventions. Fertility outcomes were promising, with 72% of patients able to conceive post - treatment, though many experienced anxiety and depression during care. This study highlights the need for early diagnosis, effective treatment, and comprehensive psychosocial support to optimize outcomes for GTN patients. Further research is needed to explore long - term effects and improve awareness of this condition.

Source: International Journal of Science and Research (IJSR)

DOI: 10.21275/sr241209123034

Authors: Jyothi Job, Akshay Kumar K K, Jyoti Ramesh Chandran, Bindu Vijay Kumar

Institution: Government Medical College

Language: English

Topic: Gestational Trophoblastic Disease Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405294700