Work

Towards precision medicine in Glioblastoma: Unraveling MGMT methylation status in glioblastoma using adaptive sparse autoencoders

Year: 2024

Type: article

Abstract: Glioblastoma is a type of cancer known for its fast growth, invasive behavior, and resistance to different treatments. It accounts for more than 50% of all malignant brain tumors. Due to its complexity, it is crucial to customize treatment plans according to each patient’s needs. The methylation status of O-6-methylguanine-DNA methyltransferase (MGMT) is a crucial biomarker (Butler et al., 2020) for predicting patient response to treatment plans and plays a critical role in the treatment response and prognosis of patients with glioblastomas, which is an aggressive form of brain cancer. It is difficult to predict the MGMT methylation status using existing methods due to the heterogeneous contrast appearance, substantial variability within lesions, and irregular enhancement patterns associated with the MGMT signature in MR images. In this work, we propose a novel method ADAptive sParse auToencoders (ADAPT) to determine the methylation status of MGMT promoter gene from the signatures present in the MRI images. Our approach involves learning features by repeatedly producing artificial MRI images, followed by a tailored sparse autoencoder that incorporates an adaptive sparse penalty to predict the MGMT methylation status. To achieve this, we designed an autoencoder neural network to generate synthetic MRI slices which extract and learn features from numerous MR sequences. We then designed sparsity restrictions by modeling an adaptive sparse penalty along with employing transfer learning to predict the methylation status of the MRI slice. The behavior of adaptive sparse penalty adjusts itself and the learning parameters in accordance with changes in the data (i.e., contrast variations, tumoural location variation etc., in MR images). The proposed technique achieves significant improvements in MRI image synthesis, preserving the brain tissue, fat, and individual tumor structures in all MRI modality images. On top of that the adaptive sparse penalty parameter resulted in the highest scores for the prediction of MGMT methylation status. Based on the cross-validation results of the ADAPT framework, the adaptive sparse penalty model performed exceptionally well in predicting the MGMT methylation status in MRI images. It achieved an overall accuracy score of 0.95, a specificity of 0.93, and a sensitivity of 0.94, demonstrating a promising potential for enhancing the interpretation of MRI data in determining MGMT methylation status, thereby contributing to improved diagnostic accuracy, as well as constructing refined personalized treatment plans.

Source: Egyptian Informatics Journal

DOI: 10.1016/j.eij.2024.100583

Authors: Sumaiya Fazal, Hafeez Ur Rehman, Moutaz Alazab

Institutions: National University of Computer and Emerging Sciences, Liverpool John Moores University, Al-Balqa Applied University

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200