p‐Anisil as a Versatile Catalyst for the E‐to‐Z Photoisomerization of Activated Alkenes ‐ Application in Late‐Stage Modification of Small Molecule Drugs, Di‐ and Tripeptides
Year: 2024
Type: article
Abstract: High‐throughput experimentation was employed to discover p‐Anisil as a highly effective and versatile catalysts for the E‐to‐Z photoisomerization of cinnamic acid derivatives and other activated alkenes. This new catalytic system tolerated a number of functional groups found in medicinal chemistry. The discovery enabled the preparation of previously unknown complex Z‐alkenes in two steps directly from drugs or peptides.
Authors: Thanh V. Q. Nguyen, Peter R. Hansen
Institution: AstraZeneca (Sweden)
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
Funder: AstraZeneca
OpenAlex ID: W4405310051