Omeprazole with Calcium Hydroxide’s Effectiveness as an Intracanal Medication against Enterococcus faecalis
Year: 2024
Type: article
Abstract: A BSTRACT Aims: To evaluate the effectiveness of omeprazole mixed with calcium hydroxide (Ca(OH) 2 ), as intracanal medicament in eliminating Enterococcus faecalis . Materials and Methods: Our study included 93 extracted mandibular premolars. A total of 15 μL of 0.5 McFarland standard E. faecalis (ATCC 29212) was inoculated into each canal and incubated at 36.5°C for 24 h. The specimens were divided into three groups: Group I ( n = 30), control group without intracanal medicament, Group II ( n = 30) with Ca(OH) 2 and Group III ( n = 30) with omeprazole and Ca(OH) 2 . The numbers of colony forming units (CFUs) were counted after 24 h. The same procedure was repeated after 7 and 14 days for the remaining samples. Statistical Analysis Use: Statistical analysis was performed using the analysis of variance (ANOVA) test ( P < 0.05). Results: We found a significant reduction in the colony-forming unit count in the omeprazole– Ca(OH) 2 group. In the Ca(OH) 2 group, the number of CFUs was significantly higher than in the omeprazole–Ca(OH) 2 group. Conclusion: Omeprazole mixed with Ca(OH) 2 was more effective than Ca(OH) 2 alone in eliminating E. faecalis .
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $250
OpenAlex ID: W4405317536