Year: 2024
Type: article
Abstract: Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly efficient manner is a momentous goal in the chemical society. Unfortunately, current methods for chiral induction focus primarily on a specific site. Herein, we realized the asymmetric chain-walking arylation of alkenyl alcohols for the construction of multisite tertiary and quaternary stereocenters in high yields and enantioselectivity. This new operation-friendly strategy carries substantial potential for future industrialization.
Authors: Chong Liu, Robbie Ge, Jun Chen, Hongmei Guo, Tyler A. Bartholome, Debabrata Maiti, Haibo Ge
Institutions: Texas Tech University, Indian Institute of Technology Bombay
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4405318590