Work

Stoichiometry effect on the structure, coordination and anticancer activity of gold( i / iii ) bisphosphine complexes

Year: 2024

Type: article

Abstract: P NMR showed characteristic singlet peak at ∼22 ppm for the Au(I) complexes and ∼57 ppm for the Au(III) complexes. The structure of the Au(III) complexes was further confirmed by X-ray crystallography as a 5-coordinate Au(III) complex. Although both Au(I) and Au(III) complexes showed promising anticancer activity in MDA-MB-231 (breast cancer) and BT-333 (glioblastoma) cancer cell lines and inhibited maximal mitochondria respiration in MDA-MB-231 cells, the Au(III) complexes further induce ROS accumulation and facilitate depolarization of the mitochondria membrane potential in MDA-MB-231 cells. Taken together, the synthetic approach provides a way to elucidate the effect of Au(I)/Au(III) oxidation states on structure, activity, and potential mechanism with respect to the same ligand.

Source: Dalton Transactions

DOI: 10.1039/d4dt01663g

Authors: Adedamola S. Arojojoye, Justin Holmes, Oluwatosin A. Obisesan, Sean Parkin, Samuel G. Awuah

Institutions: University of Kentucky, Markey Cancer Center

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid