Work

Carbonized Plant Powder Gel for Rapid Hemostasis and Sterilization in Regard to Irregular Wounds

Year: 2024

Type: article

Abstract: Irregularly shaped wounds cause severe chronic infections, which have attracted worldwide attention due to their high prevalence and poor treatment outcomes. In this study, we designed a new composite functional dressing consisting of traditional Chinese herb carbonized plant powder (CPP) and a polyacrylic acid (PAA)/polyethylenimine (PEI) gel. The rapid gelation of the dressing within 6-8 s allowed the gel to be firmly attached to an irregularly shaped wound surface and avoided powder detachment. In addition, through an infrared thermography analysis, a coagulation assay, and a morphological examination of regenerative tissue in animal wound models, it was found that the dressing substrates had synergistic effects on photothermal sterilization, rapid hemostasis, and anti-inflammatory activity, thereby achieving an 88% wound closure rate on the 9th day after the formation of the wound. This multifunctional hemostatic material is expected to be adaptable to irregular wounds and promote rapid wound healing.

Source: Nanomaterials

DOI: 10.3390/nano14241992