A review article on Ophthalmic Preparation by Using Transitional Metal Complex Synthesised from Hedychium Coronarium Leaf for the treatment of Diabetic Cataract
Year: 2024
Type: article
Abstract: Diabetes cataract is one the most common endocrinological disorder which is globally affecting a large number of the persons. Uncontrolled diabetes may trigger secondary delirious complications affecting the kidneys, eyes, cardiovascular system and central nervous system. Elevated blood glucose level causes detrimental secondary ocular complications like diabetic cataract, diabetic retinopathy, diabetic keratanopathy, diabetic glaucoma and diabetic papillopathy. In this work we evaluated the role of the nicotine exacerbation on the diabetic cataract and evaluated the pharmacological approach in management of the diabetic cataract using transitional metal coordination complex. The extensive literature survey was done to find suitable candidates for the ligand and metal ion for the metal coordination synthesis which not only manage the diabetes but also improves the damage done to the lens due to cataract caused by diabetic cataract. The rationale behind selecting the transitional as metal ion for the complex was the insulinomimetic effect of transitional metal salts and NSAID was selected because of the previous reported beneficial effects of NSAID against diabetic complications due to reduction in oxidative stress as well as in inflammatory mediators like interleukins. The complex was synthesized using as metal ion and NSAID as the ligand. The synthesized complex was evaluated for physiochemical properties and structural confirmation. The current work also explore the role of ophthalmic drug delivery system effect against diabetic cataract, to design a system with maximum effect and minimum obnoxious effects.
Institution: Bhagwant University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405326838