Year: 2024
Type: article
Abstract: Small-animal virtual reality (VR) systems have become invaluable tools in neuroscience for studying complex behavior during head-fixed neural recording, but they lag behind commercial human VR systems in terms of miniaturization, immersivity and advanced features such as eye tracking. Here we present MouseGoggles, a miniature VR headset for head-fixed mice that delivers independent, binocular visual stimulation over a wide field of view while enabling eye tracking and pupillometry in VR. Neural recordings in the visual cortex validate the quality of image presentation, while hippocampal recordings, associative reward learning and innate fear responses to virtual looming stimuli demonstrate an immersive VR experience. Our open-source system's simplicity and compact size will enable the broader adoption of VR methods in neuroscience.
Source: Nature Methods
Institution: Cornell University
Language: English
Subfield: Human-Computer Interaction
Field: Computer Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $12,290
Awards: Imaging neural activity changes underlying the acute rescue of memory function after improving cerebral blood flow in Alzheimer's disease mouse models, G7619617277, G8442864525, G8584467280, Metabolic and neural activity normalization by cerebral blood flow increase in AD/ADRD models, Stalled capillary flow: a novel mechanism for hypoperfusion in Alzheimer disease
OpenAlex ID: W4405328831