Year: 2024
Type: article
Abstract: This study aims to analyze the role of microRNAs in the pathogenesis of atherosclerosis, focusing on their coding potential and application in clinical practice. Background. Atherosclerosis is a leading cause of cardiovascular mortality worldwide, significantly impacting public health. MicroRNAs, as key regulators of gene expression, play a crucial role in the pathogenesis of atherosclerosis, offering novel avenues for diagnostics and therapeutics. Materials and methods. A review of contemporary literature was conducted to explore the link between non-coding molecules and atherosclerosis. Data from clinical studies identifying microRNAs as potential biomarkers and therapeutic targets were included. Results.The findings demonstrate that microRNAs influence critical stages of atherosclerosis pathogenesis, such as inflammation, apoptosis, and lipid metabolism. Their use as diagnostic biomarkers enhances the early detection of atherosclerosis, while their therapeutic potential presents new opportunities for treatment. Conclusion. MicroRNAs represent a promising tool for managing cardiovascular diseases. Further research is necessary to develop effective diagnostic and therapeutic strategies.
Source: Cardiology of Uzbekistan.
Authors: Д Юсупалиева, У Низамов, Р Алиева, Ш Ахмедова, А Шек
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4405329351