Work

Insulin activates parasympathetic hepatic-related neurons of the paraventricular nucleus of the hypothalamus through mTOR signaling

Year: 2024

Type: article

Abstract: Increased peripheral insulin concentrations are known to decrease hepatic glucose production through both direct actions on hepatocytes and central autonomic networks. Despite this understanding, how (and in which brain regions) insulin exerts its action is still obscure. Here, we demonstrate that insulin activates parasympathetic hepatic-related PVN neurons (PVN hepatic ) and that this effect relies on mammalian target of rapamycin (mTOR) signaling, suggesting that insulin modulates hepatic function through autonomic pathways involving insulin receptor intracellular signaling cascades.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00284.2024

Authors: Karoline Martins dos Santos, Sandy E. Saunders, Vagner R. Antunes, Carie R. Boychuk

Institutions: The University of Texas at San Antonio Health Science Center, Universidade de São Paulo, University of Missouri

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Instituto Nacional de Ciência e Tecnologia da Criosfera, National Heart, Lung, and Blood Institute