Year: 2024
Type: article
Abstract: Objectives: 1.To study the pattern of uptake of Non Invasive Prenatal Screening (NIPS) in the current Indian screening scenario & analysis of NIPT results, implications on decision-making 3. To formulate protocols to simplify use of NIPT in our scenario Methods: Retrospective observational study January 2020 to January 2023 540 women who opted for NIPT Analyzed on following parameters Á Indications of NIPT Á USG correlation Á Decision making The indications, advantages, limitations of NIPS were reviewed.Results: Of the 540 women in the study, 211 were from the intermediate risk group after combined screening and 68 from the low risk group.96 women did NIPS without having a combined screening test, only on the basis of USG markers.Amongst 540 NIPS, 26 came back as high risk for Trisomy 13/18/21 or Sex chromosomes.Of the 26 high risk NIPS, 17 were confirmed as Trisomy 21, 2 were Trisomy 18 and 7 were normal on amniocentesis.31 women with 'low risk NIPS' had fetuses with showed major anomalies later in pregnancy.Conclusions: What is already known: Although is it assuring to have a non-invasive prenatal screening with excellent accuracy as NIPS-case selection, interpretation of the report, and further decision-making should follow standardized protocols.What this study adds?NIPS is excellent for Downs syndrome; but abnormal USG markers can be seen in various other abnormalities other than Downs syndrome.Hence, if combined screening risk is high, or there are abnormal markers on USG-invasive testing and thorough serial USGs for evolving anomalies is recommended, rather than a falsely re-assuring NIPS.This study enables the clinician to be updated with NIPT indications, limitations, advantages and interpretations.
DOI: 10.1111/jog.16160
Authors: 1.To study the pattern of uptake of Non Invasive Prenatal Screening (NIPS) in the current Indian screening scenario & analysis of NIPT results, implications on decision-making 3. To formulate protocols to simplify use of NIPT in our scenario
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405331217