Prevalence and factors associated with high risk for obstructive sleep apnea in schizophrenia spectrum disorder patients on long-term clozapine
Year: 2024
Type: article
Study design: Observational Study
Abstract: Aim: This study aimed to evaluate the prevalence of obstructive sleep apnea (OSA) and its correlates among schizophrenia spectrum disorder patients receiving clozapine. Methods: For this, 200 schizophrenia spectrum disorder patients receiving clozapine for at least one year were assessed on the Berlin Sleep Questionnaire for OSA. Results: was used, the prevalence of OSA was 36%. A high risk for OSA is associated with a higher prevalence of depression, a higher number of psychiatric comorbidities, diabetes mellitus, a higher mean total chlorpromazine equivalent dose, a higher number of total medications, poorer quality of life in some of the domains, and scored high for all domains and the total score of UKU. Conclusion: To conclude, this study suggests that a high risk of OSA is associated with the presence of depression, a higher number of psychiatric comorbidities, diabetes mellitus, use of higher total chlorpromazine equivalent dose, the total number of medications, poorer quality of life, and a higher prevalence of other side effects.
Source: Indian Journal of Psychiatry
Authors: Rika Rijal, Sandeep Grover, Subho Chakrabarti, Swapnajeet Sahoo
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405331346