Work

Total synthesis of (−)-flueggenine A and (−)-15′- epi -flueggenine D

Year: 2024

Type: article

Abstract: -flueggenine D. The key step involved a novel reductive Heck dimerization strategy, utilizing a silyl-tethered enone coupling partner to ensure the desired reactivity and stereoselectivity. This dimerization method, combined with established chemistry explored en route to (-)-flueggenines C and D, offers a comprehensive synthetic approach for accessing all known RC-based oligomeric securinega alkaloids.

Source: Chemical Science

DOI: 10.1039/d4sc07525k

Authors: Seung Mo Seo, Dongwook Kim, Taewan Kim, Sunkyu Han

Institutions: Korea Advanced Institute of Science and Technology, Institute for Basic Science

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Research Foundation, National Research Foundation of Korea, Korea Advanced Institute of Science and Technology

Awards: G1399017372, G3162464001, G5935959651, G806604504, G8429067459