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U-Shaped Relationship Between MSpO2 Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study

Year: 2024

Type: article

Abstract: Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO 2 ) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort. Methods: A total of 1006 elderly patients diagnosed with OSA through polysomnography (PSG) from January 2015 to October 2017 were enrolled. Patients were stratified into four groups according to their MSpO 2 levels to assess differences in frailty onset. Multivariate Cox regression analysis, Kaplan-Meier curves, restricted cubic splines, and subgroup analyses were employed to evaluate variations in frailty onset across different MSpO 2 levels. Results: Over a median follow-up period of 52 months, 275 patients developed frailty. Analysis using restricted cubic splines revealed a U-shaped trend between MSpO 2 and frailty risk (non-linear p- value = 0.028). Patients in the lowest quartile (MSpO 2 < 91.6%) exhibited a higher risk of frailty (hazard ratio [HR] = 1.43, 95% confidence interval [CI] 1.03– 1.97, P = 0.029) compared to those in the third quartile (MSpO 2 93– 95%). Subgroup and sensitivity analyses confirmed the robustness of the U-shaped relationship. Conclusion: There is a U-shaped association between MSpO 2 and frailty among patients with OSA. Enhancing MSpO 2 levels may mitigate the risk of frailty and improve prognosis in this population. Keywords: obstructive sleep apnea, frailty, mean pulse oxygen saturation, elderly

Source: Clinical Interventions in Aging

DOI: 10.2147/cia.s489962