Work

Ruthenium-catalyzed three-component tandem remote C–H functionalization of naphthalenes: modular and concise synthesis of multifunctional naphthalenes

Year: 2024

Type: article

Abstract: P(iii)-assisted ruthenium-catalyzed remote C-H functionalization. This protocol not only tolerates various functional groups, but can be applied to many natural product and drug derivatives, and can involve a three-component reaction with two different bioactive molecules. Mechanism studies indicated that the utilization of tertiary phosphines as auxiliary groups is the key to achieving the three-component free-radical reaction.

Source: Chemical Science

DOI: 10.1039/d4sc06846g

Authors: Mao-Gui Huang, Yue-Liu-Ting Fu, Jia-Wei Li, Yue-Jin Liu

Institutions: Hubei University, Zhoukou Normal University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Zhoukou Normal University, Henan Provincial Science and Technology Research Project

Awards: G6635452100, G7632833884