Work

Iodine promoted one-pot synthesis of flavones

Year: 2024

Type: article

Abstract: A novel one-pot methodology for the synthesis of flavones starting from simple precursors such as 2′-hydroxyacetophenone and benzaldehyde derivatives in pentan-1-ol (a green solvent), without additives, mediated by iodine and with short reaction times (1 h) is described. A scope of 21 products in yields ranging from 28 % to 90 % is presented. Results demonstrated that the yield was enhanced by the use of benzaldehyde derivatives with activating substituents on the para -position.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2024.101968