Work

Sc(OTf)3‐Catalyzed Tunable Thio‐(3+3) Annulation Reactions of Indoline‐2‐thiones with α‐Benzylidene‐β‐tetralones

Year: 2024

Type: article

Abstract: A Sc(OTf)3‐catalyzed tunable thio‐Michael addition/nucleophilic addition/dehydration reaction of indoline‐2‐thiones with α‐benzylidene‐β‐tetralones was realized, leading to biologically important tetrahydrobenzo[7,8]isothiochromeno[3,4‐b]indoles and thiazino[3,2‐a]indoles in moderate to good yields. Moreover, by extending the reaction time, the dehydrogenated cycloadducts dihydrobenzo[7,8]isothiochromeno[3,4‐b]indoles were also obtained from the reaction of indoline‐2‐thiones with α‐benzylidene‐β‐tetralones.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202400452

Authors: Yan Jiang, Hao‐Jie Ma, Chen‐Ying Zhai, Xue‐Long Wang, Yi Yang

Institution: Sichuan University of Science and Engineering

Language: English

Topic: Synthesis and Reactivity of Sulfur-Containing Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Sichuan University of Science and Engineering, Sichuan University

Award: G3808017262