The relationship between the age of onset of hypertension and chronic kidney disease: a cross-sectional study of the American population
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background Hypertension can damage multiple target organs. The younger the age of onset of hypertension is, the greater the risk of cardiovascular disease (CVD) and cardiovascular death. Chronic kidney disease (CKD) is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD. Objective We investigated the relationship between the age of onset of hypertension and CKD. Method We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2007–2018. A total of 30,613 participants were assigned to one of four groups. Group 1, no hypertension ( n = 19,516); Group 2, age of onset <35 years ( n = 2,180); Group 3, 35≤ age of onset <45 years ( n = 2,128); and Group 4, age of onset ≥45 years ( n = 6,789). Logistic regression analysis was used to evaluate the relationship between the age of onset of hypertension and CKD. Results After adjusting for potential confounders, a younger age at onset of hypertension was associated with a greater risk of developing CKD compared with the absence of hypertension (Group 2 OR: 2.52, 95% CI: 1.53–4.14, P < 0.001; Group 3 OR: 1.59, 95% CI: 1.01–2.51, P = 0.048; Group 4 OR: 1.54, 95% CI: 1.00–2.38, P = 0.050). Conclusions There was a strong association between the age of onset of hypertension and CKD. The younger the age of onset of hypertension is, the greater the risk of CKD.
Authors: Lanlan Qiu, Bo Wu
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
OpenAlex ID: W4405345745