Work

Guest Diffusion Versus Recrystallization in A Single Crystal: Two Growing Mechanisms for Griseofulvin Clathrates

Year: 2024

Type: article

Abstract: Griseofulvin represents a rare case of a close-packed organic apohost that can clathrate selected volatile guests in a solid-gas fashion. Inclusion mechanisms and solvent exchange were investigated by a combination of single crystal and powder X-ray diffraction, coupled to optical microscopy and thermal analyses. In particular, gas diffusion and dissolution/recrystallization are alternatively observed, depending on the host polymorph, as well as the chemical nature of the guest and its physical state.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202403488

Authors: Enrico Spoletti, Mariana O. Diniz, Michael Svärd, Åke Rasmuson, Sarah P. Hudson, Matteo Lusi

Institutions: University of Limerick, Science Foundation Ireland, Synthesis and Solid State Pharmaceutical Centre, KTH Royal Institute of Technology

Language: English

Topic: Crystallography and molecular interactions

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funders: Science Foundation Ireland, Vetenskapsrådet, Bernal Institute, University of Limerick