Year: 2017
Type: article
Abstract: The prevalence of overweight and obesity is currently increasing worldwide. Obesity is a risk factor of cardiovascular disease and Type 2 diabetes mellitus. In obese individuals, metabolic, dyshormonal, and hemodynamic changes directly affect myocardial structure and function. Mitochondrial dysfunction and oxidative stress, insulin resistance and hyperglycaemia, dysadipokinemia, and direct lipotoxic effects of lipids and free fatty acids on myocardium are important pathogenetic mechanisms of cardiac remodelling and cardiac functional changes in obesity. Better understanding of these mechanisms could lead to the development of pharmacological methods of metabolic normalisation and inhibition of cardiac lipotoxic effects, in order to prevent chronic heart failure and other cardiovascular events in obese patients.
Authors: Г. А. Чумакова, Н Г Веселовская, А. А. Козаренко, И.В. Воробьева
Institution: Altai State Medical University
Language: Russian
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2786147097