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Efficacy of intravenous dexmedetomidine versus lidocaine on postoperative gynecological surgery: Systematic review and meta-analysis

Year: 2024

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: Aims: This study aimed to assess the efficacy of dexmedetomidine and lidocaine in gynecological postoperative follow-up. Methods: This study was conducted by using scientific databases (Scopus, ScienceDirect, Springer Link, and PubMed) to search for randomized controlled studies comparing intravenous dexmedetomidine and lidocaine in gynecological surgery patients with postoperative outcomes. Results: Out of 236 articles, four articles were included for analysis. Dexmedetomidine reduced the VAS score in 2 h (MD -0.30, p=0.001), 12 h (MD -0.39, p=0.004), and 24 h (MD -0.15, p=0.03) after operation. Additionally, the combination of dexmedetomidine and lidocaine reduced the VAS score in 2 h (MD -‍0.70, p<0.001) and 12 h (MD -0.81, p=0.03) after the operation. Conclusion: Thus, dexmedetomidine was more potent in reducing postoperative pain after gynecological surgery compared to lidocaine. Furthermore, the combination of these regiments provided better outcomes.

Source: Journal of Pharmacy & Pharmacognosy Research

DOI: 10.56499/jppres23.1754_12.s1.4

Authors: Aiman Hilmi Asaduddin, Azkia Rachmah, Taufik R.H. Kusuma, Mentari M. Sholihah

Language: English

Topic: Anesthesia and Pain Management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405354610

FWCI:

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