Work

Insight into the Key Factors that Influence the Reaction Pathways in the Silyl‐Prins Cyclization of gem‐Vinylsilyl Alcohols

Year: 2024

Type: article

Abstract: This work provides an in‐depth analysis of the factors governing the different reaction pathways in the acid‐catalyzed cyclization of gem‐vinylsilyl alcohols with aldehydes. The study evaluates the impact of both the ligands attached to silicon and the choice of the Lewis acid on the reaction outcome. Additionally, computational studies offer valuable insights into the mechanism that control these distinct pathways. The process enables the chemo‐ and stereocontrolled formation of a variety of structural frameworks, offering significant potential for the generation of a broad range of molecular architectures.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202401437

Authors: Paula González‐Andrés, Carlos Díez‐Poza, Laura F. Peña, Daniel Gónzalez‐Pinardo, Israel Fernández, Asunción Barbero

Institutions: Universidad de Valladolid, Universidad Complutense de Madrid, ORFEO-CINQA Research Network

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

Funders: Comunidad de Madrid, Universidad de Valladolid, Junta de Castilla y León, Agencia Estatal de Investigación