Work

Solvent-free and eco-friendly green protocol for N-Boc Protection of amines using picric acid as a catalyst

Year: 2024

Type: article

Abstract: We have developed an environmentally conscious green protocol to protect amine functional groups in drug discovery and the total synthesis of biologically active natural products. This method utilizes di- tert -butyl dicarbonate ((Boc) 2 O) to protect aromatic and aliphatic amines, with readily available picric acid (2 mol%) serving as a Brønsted acid catalyst. This approach enables rapid and high-yield (up to 98 %) protection of amines under completely solvent-free and eco-friendly conditions, thereby promoting a cleaner and more sustainable synthetic process.

Source: Tetrahedron Green Chem

DOI: 10.1016/j.tgchem.2024.100061

Authors: Ramesha Thongolla, Ummareddy Venkata Subba Reddy, Sailam Sri Gogula, Empati Raja Sekhar, Puchakayala Muralidhar Reddy, Anren Hu

Institutions: Osmania University, Tzu Chi University

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,800

Funders: National Science and Technology Council, Tzu Chi University, Council of Scientific and Industrial Research, India