Work

Patient-Reported Outcome Measures in NMDA Receptor Encephalitis

Year: 2024

Type: article

Abstract: BACKGROUND AND OBJECTIVES: The characteristics of persistent long-term symptoms and their contribution to subjective quality of life remain unclear in patients with NMDAR encephalitis. In this study, we aimed to evaluate postacute neuropsychiatric symptoms, subjective cognitive complaints, and disease coping mechanisms and identify predictors of health-related quality of life (HRQoL) after N-methyl-D-aspartate receptor (NMDAR) encephalitis. METHODS: This cross-sectional observational study investigated patients with NMDAR encephalitis in the postacute phase. Psychometric scales included assessment of neuropsychiatric symptoms (i.e., fatigue, sleep, anxiety, and depressive symptoms), HRQoL, everyday independence, metamemory (i.e., self-rated ability, satisfaction, and use of strategies), and coping strategies (i.e., self-efficacy, disease-related coping, and stress management). RESULTS: < 0.001). It is important to note that HRQoL was predicted by self-reported affective symptoms, self-efficacy, and coping behaviors in multivariable regression analyses, but not by acute disease severity or postacute physical disability. DISCUSSION: Our findings show that persistent neuropsychiatric and subjective cognitive concerns explain a large part of the reduced quality of life in patients with NMDAR encephalitis. These findings have important implications for a patient-centered postacute care and the role of disease coping strategies in the neurorehabilitation of autoimmune encephalitis.

Source: Neurology Neuroimmunology & Neuroinflammation

DOI: 10.1212/nxi.0000000000200343

Authors: Josephine Heine, Ole Jonas Boeken, Sophia Rekers, Katharina Wurdack, Harald Prüss, Carsten Finke

Institutions: Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, German Center for Neurodegenerative Diseases

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,450