Work

Rethinking cancer evolution: from genetic mutations to complex information systems in tumor reversion

Year: 2024

Type: article

Abstract: Cancer research has historically focused on the somatic mutation theory, viewing cancer as a consequence of genetic mutations. However, this perspective has limitations in explaining phenomena like tumor reversion and cancer heterogeneity. This paper introduces an alternative approach: viewing cancer as a complex information-processing system shaped by its microenvironment. By integrating historical data on tumor reversion and insights into evolutionary dynamics, I propose a reframing of cancer biology. This process-oriented perspective highlights the role of cellular plasticity and adaptive behaviors, offering new pathways for therapeutic development.

Source: Evolution Medicine and Public Health

DOI: 10.1093/emph/eoae032

Author: Mesut Tez

Institution: Sağlık Bilimleri Üniversitesi

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,702

OpenAlex ID: W4405367581