Synthesis of fluorine-containing bicyclo[4.1.1]octenes via photocatalyzed defluorinative (4 + 3) annulation of bicyclo[1.1.0]butanes with gem -difluoroalkenes
Year: 2024
Type: article
Abstract: -difluoroalkenes, which provides practical and straightforward access to the fluorine-containing bicyclo[4.1.1]octenes. Our protocol is characterized by mild conditions, broad substrate scope, excellent functional group tolerance and good to excellent yields. Notably, the ease and variety of product derivatizations further enrich the diversity and complexity of the fluorine-containing bicyclo[4.1.1] systems.
Source: Chemical Science
DOI: 10.1039/d4sc07243j
Authors: Kuan Zhang, Zhengyang Gao, Yan Xia, Pengfei Li, Pin Gao, Xin-Hua Duan, Li-Na Guo
Institution: Xi'an Jiaotong University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4405368697