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Synthesis, Characterization and X-Ray Crystal Structures of Aroylhydrazones Derived from 2-Chlorobenzaldehyde with Various Benzohydrazides

Year: 2024

Type: article

Abstract: Reaction of 2-chlorobenzaldehyde with 3-trifluoromethylbenzohydrazide, 3,5-dimethoxybenzohydrazide, 4-trifluoromethylbenzohydrazide and 2-bromobenzohydrazide, respectively, in methanol afforded four new aroylhydrazones. The newly synthesized compounds were characterized by means of elemental analysis, IR and 1H NMR spectroscopy, and their structures were further confirmed by X-ray single crystal determination. The compounds were assayed for their antibacterial activities against E. coli, P. aeruginosa, B. subtilis, and S. aureus and show interesting results.

Source: Acta chimica slovenica

DOI: 10.17344/acsi.2024.8967

Authors: Jia-Xue Liu, Shi-Yu Zhang, Meng-Xiao Tai, Wei Li, Zhonglu You

Institutions: Liaoning Normal University, Dalian Medical University, Second Affiliated Hospital of Dalian Medical University

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W4405368995

FWCI: 0.139

Cites:

Cited by: 1

Related to: 10