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47P Correlation of clinical, genetic and transcriptomic traits with PD-L1 positivity in TNBC patients

Year: 2024
Type: article
Study design: Observational Study
Abstract: Compared with other breast cancer subtypes, TNBC is characterised by higher tumour mutational burden, elevated levels of PD-L1 expression and increased levels of immune cell infiltration. Predictors of immunotherapy response are not yet fully elucidated with several responders harbouring both PD-L1- and TMB-low tumours. We investigated the clinical and molecular traits associated with PD-L1 expression in TNBC patients with the aim to uncover distinct signatures that may impact on PD-L1 status and could potentially explain divergent responses to ICIs.
DOI: 10.1016/j.iotech.2024.101007
Authors: A. Semertzidou, S. Hassanieh, E.M. Wigmore, O. Arqués, Z. Lai, A.E. Storti, M. Heininen-Brown, S. Willis, B. Nuttall, M. Scaltriti, R. Stewart, E. De Bruin, H. Angell
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,170
OpenAlex ID: W4405373954
FWCI:
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Related to: 10