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226P Profiling of gastric adenocarcinomas from EU and LATAM countries identifies distinct tumor immune subgroups and a central role of the tumor microbiome in shaping the immune microenvironment

Year: 2024
Type: article
Study design: Observational Study
Abstract: Gastric cancer (GC) is in the top list of most deadly cancers worldwide. Previous large-scale multi-omics studies have identified clinically relevant subgroups of patients. However, patients from European (EU) and especially Latin American (LATAM) countries are underrepresented in these studies. The present study, which is part of the European LEGACy project, aimed to profile the molecular and immunological features of GCs from EU and LATAM countries and explore leads for alternative treatment strategy.
DOI: 10.1016/j.iotech.2024.100979
Authors: M. Cabeza Segura, T. van Schooten, R. Ferreira, E. Ruiz, C. Caballero, J.M.R. O'Connor, A. Riquelme, G.I. Owen, M. Garrido, M. Díez García, M. Alsina Maqueda, F. Lordick, J. Farrés, A. Miralles, R. Dienstmann, F. Carneiro, A. Cervantes, S. Derks, T.C. Fleitas
Institutions: INCLIVA Health Research Institute, Amsterdam University Medical Centers, Amsterdam UMC Location Vrije Universiteit Amsterdam, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Instituto Nacional de Cancerología, Instituto Alexander Fleming, Pontificia Universidad Católica de Chile, Universidad Mayor, Vall d'Hebron Institute of Oncology, University Hospital Leipzig, Anaxomics (Spain), Universidade do Porto, Hospital Clínico Universitario de Valencia
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,170
OpenAlex ID: W4405374161
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