48P The A2AR antagonist inupadenant promotes humoral responses in preclinical models
Year: 2024
Type: article
Abstract: A2A receptor (A2AR) is a key mediator of adenosine immunosuppression. Inupadenant is a highly selective A2AR antagonist, which maintains full potency at the high levels of adenosine found in tumors. We recently reported that B cells are a novel cellular target of inupadenant (Martinoli et al., AACR 2023). Here, we further investigate how inupadenant modulates humoral responses in vitro, ex vivo and in vivo.
Source: Immuno-Oncology Technology
Authors: P. Tieppo, M. Mercier, S. Jung, D. Carbonez, L. Chaible, R. Marillier, F. Strozzi, M-C. Dieu-Nosjean, H. Shehade, Y. McGrath, M. Rossetti
Language: English
Subfield: Physiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,170
OpenAlex ID: W4405374789