172MO Novel regulators of antigen presentation and therapeutic reactivation of MHC-I to overcome immune evasion in small cell lung cancer
Year: 2024
Type: article
Study design: Observational Study
Abstract: Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine cancer and the addition of immune checkpoint blockade (ICB) to first-line chemotherapy for SCLC has shown modest benefits. SCLCs evade anti-tumor immunity by repressing MHC-I expression and antigen presentation (AP). We comprehensively analyzed SCLC clinical samples to identify SCLC molecular subtypes associated with MHC repression.
Source: Immuno-Oncology Technology
Authors: T. Sen, S. Chakraborty, A. Elliott, V. Jethalia, A.M. Vanderwalde, B. Halmos, D. Demircioglu, D. Hasson
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,170
OpenAlex ID: W4405374804