Year: 2024
Type: article
Study design: Systematic Review
Abstract: Roundup Placebo response in TD treatment investigatedThe placebo response in treatment for Tourette disorder (TD) is connected to certain factors, but in general, diminishing the placebo response also decreases the drug response, researchers found.They looked at the magnitude in randomized controlled trials and found that study-level factors may be manipulated by researchers to diminish placebo response.For example, this can be done by carefully selecting study sites, and keeping them at the minimum feasibility.However, differences in drug placebo may not increase, because drug response will likely diminish as well, they found.For the study, the researchers searched for placebo-controlled RCTs assessing medication interventions for TD, and calculated differences for within-group (placebo, drug) and between-group (drug-placebo) change in tics.Out of 50 RCTs involving 1,566 in the placebo meta-analysis, there was a medium-to-large placebo response.The larger placebo responses were associated with RCTs not conducted in the United States; industry sponsorship; number of centers and participants.There was also a moderate-to-high correlation between placebo and drug response.There was no significant between placebo response and drug-placebo differences.de Barros, P. M.
DOI: 10.1002/cpu30932
Author: Alison Knopf
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4405374829