Year: 2024
Type: article
Abstract: Background: Exercise training reduces tumour growth by increasing tumour-infiltrating T cell density in preclinical models.However, it remains unknown whether exercise training can modify intratumoural T cells in humans.Objective: To compare the effects of exercise training intervention versus control on human prostate intratumoural T cell density.Methods: This study is a secondary analysis of a randomised controlled trial.We randomly allocated men (age >18 years) with treatment-naïve localized prostate cancer scheduled to radical prostatectomy 2:1 to exercise training intervention or control.The exercise intervention consisted of supervised, high-intensity interval bicycling four times per week from the time of randomization until prostatectomy.Intratumoural CD3 + and CD8 + T cell densities in diagnostic biopsies and post-surgical prostatectomy specimens were quantified using immunohistochemistry. Betweengroup differences in changes from baseline to follow-up were estimated using constrained baseline linear mixed-effect models.
Source: Immuno-Oncology Technology
Authors: I. Benesova, J. Balko, V. Tovazhnianska, M. Rataj, D. Gálová, J. Smetanová, R. Lischke, J. Bartunkova, Z.O. Ozaniak Strizova, A. Ozaniak
Institutions: University Hospital in Motol, Charles University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,170
OpenAlex ID: W4405374994