Work

Blood-based sex-differential DNA methylation in Alzheimer’s disease

Year: 2024

Type: article

Abstract: Aim: We aim to explore the blood-based sex-differential DNA methylation profiles in patients with Alzheimer’s disease (AD). Methods: The same analytical pipeline and meta-analysis procedure were applied to 254 patients with AD and 261 matched healthy controls (HC) from four blood-based datasets to identify sex-differentially methylated positions (sex-DMPs) and their biological functions. We further reviewed brain-based sex-DMPs previously reported in AD and intersected with blood-based sex-DMPs. Results: We identified 134 sex-DMPs in AD, 88 were unique to AD, and 46 were shared with HC. Eleven novel sex-DMPs and 28 sex-DMPs consistent across blood and brain were recognized for the first time. Differentially methylated genes, such as COL25A1 , MSUT2 , ELAVL4 , SLC17A7 , EPHA4 , and PPP2CB , were closely related to the pathogenesis of AD. In addition, immune-related processes were enriched in the enrichment analysis. Conclusion: Sex-differential DNA methylation in blood provides potential biomarkers for AD pathogenesis, and also points to potential drug targets for precision medicine.

Source: Ageing and Neurodegenerative Diseases

DOI: 10.20517/and.2024.28

Authors: Tianmi Yang, Chunyu Li, Qianqian Wei, Yangfan Cheng, Yi Xiao, Huifang Shang

Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Exeter, National Natural Science Foundation of China, Universidade de Macau, University of California, Los Angeles