ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement
Year: 2024
Type: article
Study design: Case Report
Abstract: Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are autoimmune diseases characterized by inflammation of small to medium blood vessels. This case explores AAV pathophysiology, its link to bronchiectasis and leucocytoclasia, ANCA positivity, and current treatment guidelines.Case Presentation: A 48-year-old with abdominal pain, rash, hypertensive urgency, and respiratory symptoms was diagnosed with AAV, confirmed by skin biopsy and positive C-ANCA, stool occult blood with negative abdominal imaging along with bronchiectasis on HRCT. The patient initially failed to respond to broad-spectrum antibiotics but improved with high-dose corticosteroids.Conclusion: We highlight an atypical presentation of AAV, showing the importance of timely immunosuppressive therapy for favorable outcomes.
Source: Sri Lanka Journal of Medicine
Authors: N. M. M. Risly, I. K. Jayasinghe, N. Athauda, E. M. C. B. Ekanayake, S. Hettige, J. F. Sahana
Institutions: Teaching Hospital Kandy, University of Peradeniya
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405381783